Priming by motion too rapid to be consciously seen

Too True to be Bad

Psychology journals rarely publish nonsignificant results. At the same time, it is often very unlikely (or “too good to be true”) that a set of studies yields exclusively significant results. Here, we use likelihood ratios to explain when sets of studies that contain a mix of significant and nonsignificant results are likely to be true or “too true to be bad.” As we show, mixed results are not ...

Too much alike to be receptive

accumulate during the process of fibril formation are thought to cause the neuronal toxicity associated with the onset and progression of Parkinson’s disease. Little is known about the detailed structural properties of aS oligomers and the molecular mechanisms that lead to their toxicity. Fusco et al. report the structural characterization of two forms of aS oligomers, which elucidates the fund...

Infective endocarditis: too ill to be operated?

Infective endocarditis remains a disease associated with high mortality in certain groups of patients, with death resulting primarily from central nervous system complications and congestive heart failure. Combined medical and surgical therapy reduces both early and late mortality in complicated cases, especially in patients with valvular dysfunction related to heart failure. In these patients,...

Are we too busy to be happy?

LCZ696: too good to be true?

This issue of the European Heart Journal contains a major statement by the PARADIGM-HF Investigators, who present an ‘putative placebo’ analysis for LCZ696, a new medicine that yielded a remarkable reduction in total mortality and heart failure events in patients with significant heart failure with reduced ejection fraction (HF-REF). (NB: I serve as a consultant on Novartis’s cardiovascular–met...